Fresh analysis indicates that individuals who stop using blockbuster GLP-1 drugs like semaglutide or tirzepatide may regain shed pounds far faster than those who end conventional lifestyle plans.
Research printed in a leading health publication shows that while obese people frequently drop substantial amounts of their total mass while undergoing treatment, the weight is regained at an average rate of nearly a kilo each month after stopping.
"Individuals buying these drugs should be cognizant of the potential of fast weight regain when the therapy concludes," warns expert Dr. Susan Jebb.
This pace of regain implies a return to original weight in about 18 months.
Analyzing Approaches
The study, which looked at dozens of studies involving thousands of participants, compared the effects of GLP-1 agonists with older methods.
The team point out that individuals who shed pounds through diet and exercise usually have a slower weight regain—around 0.1 kg a month—after stopping.
The Reason for the Quick Regain
Experts believe the mode of action of the jabs accounts for the heightened regain.
The injections mimic a body's own chemical called GLP-1, which helps regulate appetite.
"Sustained high doses of GLP-1 levels several times higher than normal may cause the system to generate a reduced amount of its endogenous GLP-1, and may also lessen responsiveness to its effects," explained Dr. Adam Collins, a nutrition researcher.
"Stopping of this medication means appetite is uncontrolled, making overeating a significant risk."
A Lifelong Condition?
Health authorities recommend the injections for individuals with weight-linked health risks, alongside prescribed lifestyle changes.
Professionals argue that, due to the high risk of relapse, the treatment is often long-term.
This view is supported by drug manufacturers, who state that the results "underscore the persistent nature of excess weight," akin to managing conditions like hypertension.
Patient Experiences
Individuals who have discontinued the jabs explain a powerful return of appetite.
"It was like a switch that goes on and I was suddenly starving," described one woman.
This challenge is exacerbated if individuals have not established sustainable lifestyle or habit changes during therapy.
Widespread Use
Recent estimates show that millions of adults in the UK have tried weight-loss jabs in the past year, with interest remaining high.
- Use is more common among females compared to males.
- The 40s and 50s age group shows the greatest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
Ultimately, experts emphasize that while these medications are effective agents for weight loss, they are not a standalone fix and maintained weight loss hinges on combined lifestyle changes.
